Hulley Group | Integrated musculoskeletal tissue modelling

Botnar Tissue remodelling and regeneration

Hulley group research is directed towards understanding skeletal tissue disease pathology and devising effective regenerative strategies.

Human mini-bone — Osteocytes and osteoblasts in self-assembling organotypic mini-bone

The group combines human tissue omics with organotypic culture approaches. 3D multi-lineage organotypic bones and tendons are generated from patient-derived human primary cells or iPSC with CRISPR mutations. These are used for drug discovery and rare bone disease modelling. Multiphasic tissues are currently in development. Ongoing comparison is made to data derived from single cell atlases of bone and tendon, as well as large scale synovial fluid proteomics studies.