Group Leader in Systems Biology and Next Generation Sequencing Analysis
I completed my Ph.D. in molecular T cell immunology at Imperial College London in May 2013 and, after a two-year period of working as a post-doctoral scientist investigating the epigenetics of T cell activation at the University of Oxford; I was successful at applying for a highly competitive 3 year MRC Fellowship in Computational Biology (Computational Genomics and Training Centre (CGAT) program), also at the University of Oxford.
As a result of my extensive computational training at CGAT, I have developed a number of core competencies in statistics, mathematics and software development, enabling the difficult analysis and interpretation of next-generation sequencing data. It was during this time that I developed a strong appreciation of the power of combining different 'omics' datasets to facilitate drug discovery. As such, I have been involved in a number of collaborations across a wide range of disease models to identify potentially draggable targets using systems biology tools.
Following the completion of my MRC fellowship I was appointed group leader in systems biology at the Botnar research Centre.
Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.
Cribbs A. et al, (2018), The journal of biological chemistry, 293, 2422 - 2437
Science and Bioethics of CRISPR-Cas9 Gene Editing: An Analysis Towards Separating Facts and Fiction.
Cribbs AP. and Perera SMW., (2017), The yale journal of biology and medicine, 90, 625 - 634
Selective modulation of Natural Killer (NK) cell phenotypes through chromatin modifying mechanisms
Cribbs A. et al, (2016), 46, 68 - 69
Production and Concentration of Lentivirus for Transduction of Primary Human T Cells.
Kennedy A. and Cribbs AP., (2016), Methods in molecular biology (clifton, n.j.), 1448, 85 - 93
Role of the Kynurenine Pathway in Immune-Mediated Inflammation
Cribbs AP. and Williams RO., (2015), Targeting the Broadly Pathogenic Kynurenine Pathway