Group Leader in Systems Biology and Next Generation Sequencing Analysis
I completed my Ph.D. in molecular T cell immunology at Imperial College London in May 2013 and, after a two-year period of working as a post-doctoral scientist investigating the epigenetics of T cell activation at the University of Oxford; I was successful at applying for a highly competitive 3 year MRC Fellowship in Computational Biology (Computational Genomics and Training Centre (CGAT) program), also at the University of Oxford.
As a result of my extensive computational training at CGAT, I have developed a number of core competencies in statistics, mathematics and software development, enabling the difficult analysis and interpretation of next-generation sequencing data. It was during this time that I developed a strong appreciation of the power of combining different 'omics' datasets to facilitate drug discovery. As such, I have been involved in a number of collaborations across a wide range of disease models to identify potentially draggable targets using systems biology tools.
Following the completion of my MRC fellowship I was appointed group leader in systems biology at the Botnar research Centre.
Invasive Salmonella exploits divergent immune evasion strategies in infected and bystander dendritic cell subsets
Aulicino A. et al, (2018), Nature Communications, 9
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors
Vazquez-Rodriguez S. et al, (2018), Angewandte Chemie International Edition
Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells
Cribbs A. et al, (2018), Journal of Biological Chemistry, 293, 2422 - 2437
Science and Bioethics of CRISPR-Cas9 Gene Editing: An Analysis Towards Separating Facts and Fiction.
Cribbs AP. and Perera SMW., (2017), Yale J Biol Med, 90, 625 - 634
Selective modulation of Natural Killer (NK) cell phenotypes through chromatin modifying mechanisms
Cribbs A. et al, (2016), 46, 68 - 69