Contact information
Websites
-
Cribbslab website
The cribbslab laboratory website
-
Personal website
My personal website detailing my background, code and personal opinions
-
Linkedin
Linked in website
Colleges
Adam Cribbs
ASSOCIATE PROFESSOR
- MRC Career Development Fellow
Prof Cribbs leads a computational biology team with a broad interest in systems biology, immunology, epigenetics, and machine learning-driven approaches to biomedical research.
He completed his PhD in molecular T cell immunology at Imperial College London in May 2013. He then undertook a two-year postdoctoral position investigating the epigenetics of T cell activation at the University of Oxford. Following this, he completed a three-year MRC Fellowship in Computational Biology (Computational Genomics and Training Centre (CGAT) programme) with Prof Chris Ponting, also at the University of Oxford. Upon completion of this fellowship, he was appointed Group Leader in Systems Biology in 2018 and MRC Career Development Fellow (2021–2026) at the Botnar Research Centre.
Research in the Cribbs lab integrates functional genomics with advanced machine learning approaches to understand disease biology. A key focus is the development and application of graph-based neural networks, causal machine learning, and Agentic AI systems to identify regulatory mechanisms governing gene expression, protein interactions, and biological pathways. By leveraging these methodologies, the lab aims to decipher disease processes and uncover novel therapeutic targets.
Recent publications
Separate transcription and splicing gene networks are linked and coordinated by the pRb-E2F pathway.
Journal article
Carr SM. et al, (2026), Nucleic Acids Res, 54
TF4-mediated stress response as a therapeutic vulnerability in chordoma.
Journal article
Cottone L. et al, (2025), Mol Oncol
Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon
Preprint
Cohen CJ. et al, (2025)
Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis.
Journal article
Marzeda AM. et al, (2025), Ann Rheum Dis, 84, 1484 - 1500
Biomolecular tracking by FIRESCAPE reveals distinct modes of clearance, damage induction and cellular uptake for extracellular histone H3
Preprint
Josephson B. et al, (2025)