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Oppermann Group | Epigenetic Mechanisms in Musculoskeletal Disease

Botnar

The research in our group focuses on target identification and validation in a spectrum of human diseases including benign and malignant soft tissue tumours or hematological malignancies affecting the skeleton such as multiple myeloma, and inflammatory conditions including endometriosis, cardiovascular disease, or autoimmune diseases.

Microscopy experiment showing p53-MDM2 interactions as a red dots in breast cancer cells. Image by Nadia Halidi.

The use of chemical, molecular and structural biology, combined with single-cell imaging and sequencing technologies provides a platform for us to understand human biology and is a major focus of the group. These approaches are currently applied to identify and validate epigenetic or metabolic mechanisms in stem cell biology, as well as chronic inflammatory, malignant and benign proliferative diseases.

In particular, our aim is to identify possible novel therapeutic intervention points in malignant such as bone and soft tissue cancers like sarcoma or in multiple myeloma, and in inflammatory or fibrotic conditions including arthritis and ankylosing spondylitis, cardiovascular disease, endometriosis or uterine fibroids. These goals are pursued in highly collaborative projects, such as the Oxford-Bayer Alliance in Women's Health and the Oxford Centre for Translational Myeloma Research.

Chemical tools such as selective and cell-active inhibitors are important in understanding biological systems. We pursue the development and characterisation of chemical tools for epigenetic biology within the Epigenetic Probe Project, a public-private partnership between the Structural Genomics Consortium (SGC) and several academic, private and patient organisations. 

 

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Social and Alumni

Social Events and Retreats

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Teams

The Oppermann group has several specialist teams

Molecular Biology

Structural Biology

Computational Biology

SMALL RESEARCH Facilities

The Botnar Research Center provides facilities for advanced research

Next Generation Sequencing

Imaging

Biomarkers

Histology

Principal Investigators

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Research Staff

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Related research themes

Oncological Conditions
Oncological Conditions
Inflammation biology
Inflammation biology
Tissue remodelling and repair
Tissue remodelling and repair
Translational medicine
Translational medicine