Chen-Yi Wang

My research journey began with a fascination for chromatin biology and epigenetics, driven by a desire to understand how chromatin structure and epigenetic modifications regulate gene expression and shape cellular functions. This curiosity gradually led me to expand beyond traditional wet-lab research into the computational analysis of genomic data, bridging experimental and bioinformatic approaches.

After training as a molecular and cellular biologist, I developed strong expertise in next-generation sequencing (NGS)and later joined Professor Oppermann’s group at the Botnar Research Centre in 2017, where I further strengthened my computational skills through the Computational Genomics Analysis and Training (CGAT) program.

Today, my work integrates experimental and computational genomics to investigate tumour biology, applying bioinformatic methods on NGS, long-read sequencing, single-cell and spatial transcriptomics to uncover disease-associated mechanisms and the molecular pathways that drive cancer progression.

Looking ahead, I aim to combine genomics, transcriptomics, proteomics, and spatial data to reveal disease heterogeneity and microenvironmental complexity, ultimately contributing to the discovery of new therapeutic targets and advancing precision medicine.