Anjan Thakurta
Statutory Professor of Translational Medicine
- Director of the translational program of the Oxford Translational Myeloma Centre (OTMC)
Prof Anjan Thakurta's goals for the OTMC are focused on advancing personalised care and cure of Multiple Myeloma. In collaboration with NDORMS and other Oxford colleagues, he leads the adoption of molecular diagnostics and minimal residual disease (MRD) assessment plans to set up a new model of clinical care in Oxford and beyond.
He also leads a cross functional team to build a Myeloma Biobank at the Botnar Institute for Musculoskeletal Sciences and large Myeloma Datahub to assist new research and collaborations.
His personal research focus is understanding the biological drivers of molecularly defined high risk or targeted Myeloma segments and clinical resistance and role of novel therapeutics to address their clinical needs.
Outside of Oxford, Anjan is involved in the development of therapeutics in cancer and neurodegenerative disease at a small biotech in Boston, Massachusetts..
Previously Prof Thakurta worked in the pharmaceutical industry in research, development and approvals of drugs and diagnostics in hematological cancers such as Multiple Myeloma and Acute Myeloid Leukemia. He led the collaborative industry-academia Myeloma Genome Project that helped establish the comprehensive landscape of newly diagnosed and relapsed and refractory Myeloma genome. He focused on the late-stage translational, and diagnostics development and approval of multiple drugs in Myeloma and Acute Myeloid Leukemia.
Professor Thakurta obtained a MSc from Jawaharlal Nehru University, Delhi and MTech from IIT, Delhi, holds a PhD in genetics from Cambridge University and did postdoctoral research at Harvard and at the National Cancer Institute, USA. He is a fellow of Reuben college.
Anjan is a foodie and likes a certain brand of beverage of Scottish variety!
Key publications
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Walker BA. et al, (2018), Blood, 132, 587 - 597
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Walker BA. et al, (2019), Leukemia, 33, 159 - 170
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Gooding S. et al, (2021), Blood, 137, 232 - 237
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Thakurta A. et al, (2019), Blood, 133, 1217 - 1221
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Mason MJ. et al, (2020), Leukemia, 34, 1866 - 1874
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Ortiz-Estévez M. et al, (2021), Bmc med genomics, 14
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Stong N. et al, (2023), Blood, 141, 1574 - 1583
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Philpott M. et al, (2021), Nat biotechnol, 39, 1517 - 1520
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Munshi NC. et al, (2017), Jama oncol, 3, 28 - 35
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Sudha P. et al, (2022), Clin cancer res, 28, 2854 - 2864
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Bjorklund CC. et al, (2015), Blood cancer j, 5
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Ansari-Pour N. et al, (2023), Blood, 141, 620 - 633
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Gooding S. et al, (2022), Blood, 140, 1816 - 1821
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Bjorklund CC. et al, (2020), Leukemia, 34, 1197 - 1201
Recent publications
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Oral azacitidine modulates the bone marrow microenvironment in patients with acute myeloid leukaemia in remission: A subanalysis from the QUAZAR AML-001 trial.
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Menezes DL. et al, (2023), Br j haematol, 201, 1129 - 1143
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High-dose melphalan treatment significantly increases mutational burden at relapse in multiple myeloma.
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Samur MK. et al, (2023), Blood, 141, 1724 - 1736
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The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM.
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Stong N. et al, (2023), Blood, 141, 1574 - 1583
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Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.
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Ansari-Pour N. et al, (2023), Blood, 141, 620 - 633
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Correction: Prolyl-tRNA synthetase as a novel therapeutic target in multiple myeloma.
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Kurata K. et al, (2023), Blood cancer j, 13