Anjan Thakurta
Statutory Professor of Translational Medicine
- Director of the translational program of the Oxford Translational Myeloma Centre (OTMC)
Prof Anjan Thakurta's goals for the OTMC are focused on advancing personalised care and cure of Multiple Myeloma. In collaboration with NDORMS and other Oxford colleagues, he leads the adoption of molecular diagnostics and minimal residual disease (MRD) assessment plans to set up a new model of clinical care in Oxford and beyond.
He also leads a cross functional team to build a Myeloma Biobank at the Botnar Institute for Musculoskeletal Sciences and large Myeloma Datahub to assist new research and collaborations.
His personal research focus is understanding the biological drivers of molecularly defined high risk or targeted Myeloma segments and clinical resistance and role of novel therapeutics to address their clinical needs.
Outside of Oxford, Anjan is involved in the development of therapeutics in cancer and neurodegenerative disease at a small biotech in Boston, Massachusetts..
Previously Prof Thakurta worked in the pharmaceutical industry in research, development and approvals of drugs and diagnostics in hematological cancers such as Multiple Myeloma and Acute Myeloid Leukemia. He led the collaborative industry-academia Myeloma Genome Project that helped establish the comprehensive landscape of newly diagnosed and relapsed and refractory Myeloma genome. He focused on the late-stage translational, and diagnostics development and approval of multiple drugs in Myeloma and Acute Myeloid Leukemia.
Professor Thakurta obtained a MSc from Jawaharlal Nehru University, Delhi and MTech from IIT, Delhi, holds a PhD in genetics from Cambridge University and did postdoctoral research at Harvard and at the National Cancer Institute, USA. He is a fellow of Reuben college.
Anjan is a foodie and likes a certain brand of beverage of Scottish variety!
Key publications
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Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Journal article
Walker BA. et al, (2018), Blood, 132, 587 - 597
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A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.
Journal article
Walker BA. et al, (2019), Leukemia, 33, 159 - 170
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Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma.
Journal article
Gooding S. et al, (2021), Blood, 137, 232 - 237
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High subclonal fraction of 17p deletion is associated with poor prognosis in multiple myeloma.
Journal article
Thakurta A. et al, (2019), Blood, 133, 1217 - 1221
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Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease.
Journal article
Mason MJ. et al, (2020), Leukemia, 34, 1866 - 1874
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Integrative multi-omics identifies high risk multiple myeloma subgroup associated with significant DNA loss and dysregulated DNA repair and cell cycle pathways.
Journal article
Ortiz-Estévez M. et al, (2021), Bmc med genomics, 14
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The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM.
Journal article
Stong N. et al, (2023), Blood, 141, 1574 - 1583
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Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq.
Journal article
Philpott M. et al, (2021), Nat biotechnol, 39, 1517 - 1520
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Association of Minimal Residual Disease With Superior Survival Outcomes in Patients With Multiple Myeloma: A Meta-analysis.
Journal article
Munshi NC. et al, (2017), Jama oncol, 3, 28 - 35
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Myeloma Genome Project Panel is a Comprehensive Targeted Genomics Panel for Molecular Profiling of Patients with Multiple Myeloma.
Journal article
Sudha P. et al, (2022), Clin cancer res, 28, 2854 - 2864
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Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.
Journal article
Bjorklund CC. et al, (2015), Blood cancer j, 5
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Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.
Journal article
Ansari-Pour N. et al, (2023), Blood, 141, 620 - 633
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Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma.
Journal article
Gooding S. et al, (2022), Blood, 140, 1816 - 1821
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Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN.
Journal article
Bjorklund CC. et al, (2020), Leukemia, 34, 1197 - 1201
Recent publications
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Dysregulated immune proteins in plasma in the UK Biobank predict Multiple Myeloma 12 years before clinical diagnosis.
Journal article
Fieggen J. et al, (2025), Blood adv
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Constructing a Computational Workflow for the Identification of Novel Cellular and Molecular Drivers of Human Granulopoiesis
Journal article
Riva SG. et al, (2024), Blood, 144, 2525 - 2525
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KLF5 Is a Key Regulator of IMiD-Induced Neutropenia
Journal article
Simoglou Karali C. et al, (2024), Blood, 144, 2527 - 2527
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Iberdomide increases innate and adaptive immune cell subsets in the bone marrow of patients with relapsed/refractory multiple myeloma.
Journal article
Van Oekelen O. et al, (2024), Cell rep med, 5
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Pharmacodynamic changes in tumor and immune cells drive iberdomide's clinical mechanisms of activity in relapsed and refractory multiple myeloma.
Journal article
Amatangelo M. et al, (2024), Cell rep med