KTRR Senior Research Fellow
I am a Senior Research Fellow of the Kennedy Trust of Rheumatology Research (KTRR) at the University of Oxford.
My previous research focused on the characterization of relevant cellular and molecular events regulating the initiation of immune responses. I completed my Ph.D. under the supervision of Jacques Nunes and Daniel Olive at the University of the Mediterranean, Marseille, France, focusing on the negative regulation of primary and leukemic T cell activation. I undertook postdoctoral training at the Netherlands Cancer Institute in Amsterdam with John Collard, where I studied polarity proteins and T cell migration. I then moved on to the laboratory of Matthew Krummel at UCSF, San Francisco, USA, where I continued to work on the molecular mechanism of T cell migration in vivo using 2-photon microscopy. In addition, I developed a broader interest in the spatio-temporal behaviour of T cells during infection and vaccination. In particular, I described a specific period during which T cells directly communicate to control each other's fate. I joined the Kennedy Institute in June 2016, where I am still exploring the dynamic of T cell immune responses.
Th1 responses in vivo require cell-specific provision of OX40L dictated by
GERARD A., (2020), Nature communications
Modes of Communication between T Cells and Relevance for Immune Responses
GERARD A. and Uhl LFK., (2020), International journal of molecular sciences
Palm MM. et al, (2020), Immunity
Krummel MF. et al, (2018), Proc natl acad sci u s a, 115, 11585 - 11590
Cai E. et al, (2018), Biophysical journal, 114, 547A - 548A