Contact information
Research groups
Erinke van Grinsven
Postdoctoral Researcher in Innate Immunity and Inflammation
Because I have a long-standing interest in neutrophil heterogeneity I came to the Genomics of Inflammation lab to explore this at the transcriptional level, after working mainly on functional and phenotypical heterogeneity during my PhD projects. Recently I have started a new project exploring morphological and transcriptional heterogeneity in further detail by studying the link between nuclear shape and genome topology. One of the most striking characteristics of the neutrophils is its lobulated nucleus, formed from a round nucleus during differentiation in the bone marrow. Nobody understands how or why this shape is formed. Deeper knowledge of neutrophil formation would help us understand why the release of immature, dysfunctional, and hyperactive neutrophils is linked to chronic inflammatory diseases and cancer.
After finishing my PhD at the University Medical Centre Utrecht in the Netherlands, I joined the Kennedy Institute in January 2019 as a postdoctoral researcher. I focus on neutrophil heterogeneity especially in mouse models of arthritis but also in homeostatic granulopoiesis.
Recent publications
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Neutrophil nucleus: shaping the past and the future.
Salafranca J. et al, (2023), J leukoc biol, 114, 585 - 594
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Macrophages in the synovial lining niche initiate neutrophil recruitment and articular inflammation.
Zec K. et al, (2023), J exp med, 220
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Analysis of Neutrophil Morphology and Function Under Genetic Perturbation of Transcription Factors In Vitro.
Salafranca J. et al, (2023), 2594, 69 - 86
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You reap what you sow: Neutrophils "plucking" platelets harvest prothrombotic effects.
van Grinsven E. and Udalova IA., (2022), Immunity, 55, 2217 - 2219
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Distinct transcription factor networks control neutrophil-driven inflammation.
Khoyratty TE. et al, (2021), Nat immunol, 22, 1093 - 1106