Colleges
Junqing (Frank) Xie
B.S.Med, MSc, DPhil
Senior Researcher in Pharmacoepidemiology and Pharmacogenomics
Real-World Study & Translational Science
Converging Statistical, Biological, and Clinical Evidence
A central thread of my work is moving from association to clinical translation: using pharmacogenomics to inform safer, more personalised prescribing; analysing real-world data mapped to common data models to support regulatory science; and drawing on large biobanks such as Our Future Health and UK Biobank to identify biomarkers and genetic determinants of aging-related and untreatable diseases. My aim is to shorten the distance between evidence generation and its application at the bedside and in policy.
Prior to my role at NDORMS, I was a Statistical Programming Training Fellow (2018–2019) at the Oxford Big Data Institute, where I gained systematic training in developing well-organised analytic pipelines for large-scale research initiatives. I received my medical training at Shandong University (Bachelor, 2015), studied Epidemiology and Biostatistics at Peking University (MSc, 2018), and completed my DPhil in Clinical Epidemiology at the University of Oxford (2023).
Key publications
Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data.
Journal article
Xie J. et al, (2024), EClinicalMedicine, 77
Relationship between HLA genetic variations, COVID-19 vaccine antibody response, and risk of breakthrough outcomes.
Journal article
Xie J. et al, (2024), Nat Commun, 15
Clinical and Genetic Risk Factors for Acute Incident Venous Thromboembolism in Ambulatory Patients With COVID-19.
Journal article
Xie J. et al, (2022), JAMA Intern Med, 182, 1063 - 1070
Comparative effectiveness of the BNT162b2 and ChAdOx1 vaccines against Covid-19 in people over 50.
Journal article
Xie J. et al, (2022), Nat Commun, 13
Association of Tramadol vs Codeine Prescription Dispensation With Mortality and Other Adverse Clinical Outcomes.
Journal article
Xie J. et al, (2021), JAMA, 326, 1504 - 1515
Recent publications
Integrative proteogenomic analyses implicate KLK13 as a glycaemia-linked circulating protein in diabetic kidney disease.
Journal article
Liu D. et al, (2026), Diabetes Res Clin Pract, 237
Prevalence, trends, and determinants of early-onset type 2 diabetes in northwest China: a sex-stratified analysis of ∼10 million community-dwelling population.
Journal article
Wang J. et al, (2026), Diabetes Res Clin Pract
Sarcopenia and Risk of Cardiovascular Events and Mortality: A Meta-analysis of Longitudinal Observational Studies.
Journal article
Wang N. et al, (2026), Can J Cardiol
Unveiling the association between low-density lipoprotein cholesterol lowering and fracture risk : real-world evidence from a target trial emulation study.
Journal article
Wen Z. et al, (2026), Bone Joint Res, 15, 227 - 237
Residential greenness, air pollution, and epilepsy: Insight in genetic susceptibility and life expectancy.
Journal article
Cui F. et al, (2026), J Adv Res
Organ-specific proteomic aging clocks predict disease and longevity across diverse populations.
Journal article
Wang Y. et al, (2026), Nat Aging, 6, 162 - 180
Synergistic effects of bisphenol A and its substitutes with latent insulin resistance on childhood blood pressure and the potential role of lipid metabolism.
Journal article
Zhang Y. et al, (2025), Environ Int, 206
Wildfire-related PM2.5 and respiratory transmitted disease among Chinese children and adolescents from 2008 to 2019: A retrospective study.
Journal article
Chen L. et al, (2025), PLoS Med, 22
Phosphodiesterase-5 Inhibition and Alzheimer's Disease Risk: A Mendelian Randomisation Study.
Journal article
Alcalde-Herraiz M. et al, (2025), Aging Cell, 24