Contact information
Research groups
Kalle Soderstrom
MSc, PhD
Honorary Departmental Senior Research Fellow.
We study the role of Natural Killer (NK) cells and other innate lymphoid cells (iLC) in chronic inflammatory diseases mainly rheumatoid arthritis (RA). We focus our studies on the development and function of tissue localized NK cells and here use epigenetic tools to decipher regulatory elements involved in NK cell subset differentiation and functional specialization within the tissue environment.
We are particularly focusing on the functional capacity of NK cells and other innate lymphoid cells to drive downstream disease relevant inflammatory pathways such as myeloid cell differentiation and activation, dendritic cell (DC) differentiation, osteoclastogenesis, and stromal cell activation.
We aim to find novel means to target such pro-inflammatory pathways using antibodies, peptides, and small molecule epigenetic inhibitors
Recent publications
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Characterization of NK Cells in Endometriosis Associated Pain.
Soderstrom K. et al, (2016), Reproductive sciences, 23, 161A - 161A
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Interleukin-15-activated natural killer cells kill autologous osteoclasts via LFA-1, DNAM-1 and TRAIL, and inhibit osteoclast-mediated bone erosion in vitro.
Feng S. et al, (2015), Immunology, 145, 367 - 379
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Interleukin-15-activated natural killer cells kill autologous osteoclasts via LFA-1, DNAM-1 and TRAIL, and inhibit osteoclast-mediated bone erosion in vitro
Feng S. et al, (2015), Immunology, 145, 367 - 379
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Balance between activating NKG2D, DNAM-1, NKp44 and NKp46 and inhibitory CD94/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Nielsen N. et al, (2014), Immunology, 142, 581 - 593
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AB0079 Synovial Explant Inflammatory Mediator Production is Correlated with Disease Activity in Rheumatoid Arthritis: A Cross Sectional Study
Andersen M. et al, (2014), Annals of the rheumatic diseases, 73, 830.1 - 830