I have a multidisciplinary research background. After BSc in Pharmacy and PhD in Physical Chemistry, I took a post-doctoral position in Oxford at Kennedy Institute of Rheumatology from 2015.
My postdoc research projects focus on finding new targets and treatments for osteoarthritis. During my postdoc period, I discovered retinoic acid metabolism blocking agents as potential disease-modifying drugs for osteoarthritis; performed the first single-nuclei RNA sequencing in normal porcine cartilage; and observed the suppression of shear-induced genes in murine knee joints under the treatment of a novel lubricant.
Zhu L. et al, (2022), Sci transl med, 14
MAINTAINING ALL-TRANS RETINOIC ACID LEVELS WITH TALAROZOLE SUPPRESSES MECHANFLAMMATION FOLLOWING CARTILAGE INJURY THROUGH A PERIXOSOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA-DEPENDENT MECHANISM
Kamalathevan P. et al, (2022), Osteoarthritis and cartilage, 30, S181 - S181
SINGLE NUCLEI RNA-SEQUENCING OF PORCINE ARTICULAR CARTILAGE UNCOVERS THE CHONDROCYTES CLUSTERS THAT CHANGE IN RESPONSE TO MECHANICAL INJURY
Zhu L. et al, (2022), Osteoarthritis and cartilage, 30, S27 - S27
TALAROZOLE, A RETINOIC ACID METABOLISM BLOCKING AGENT, SUPPRESSES MECHANOFLAMMATION AND ATTENUATES THE DEVELOPMENT OF POST-TRAUMATIC OA
Zhu L. et al, (2022), Osteoarthritis and cartilage, 30, S72 - S73
Chaudhry N. et al, (2022), Osteoarthritis cartilage