Loren Kell
DPhil (Oxon), BSc (Hons)
Postdoctoral Research Assistant in Molecular Medicine
I am a postdoctoral researcher at the Botnar Institute, supervised by Prof. Lynne Cox, Prof. Katja Simon, and Dr Ghada Alsaleh. I have investigated human immune system ageing during both my BSc Immunology and Infection at University College London and during my DPhil at Oxford. My doctoral and current research focus on interventions that rejuvenate immune responses in old age by their ability to modulate mTOR activity and DNA damage. I work both with primary human cells in vitro and with samples from human clinical trials testing anti-ageing interventions.
Key publications
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Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage
Preprint
Kell L. et al, (2025)
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The central role of DNA damage in immunosenescence.
Journal article
Kell L. et al, (2023), Front aging, 4
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The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine
Journal article
Kell DB. et al, (2025), Journal of reproductive immunology, 171
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Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System
Preprint
Nunes M. et al, (2025)
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Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.
Preprint
Alsaleh G. et al, (2025)