Contact information
https://orcid.org/0000-0003-1322-2027
Botnar Institute for Musculoskeletal Sciences, Old Rd, Headington, Oxford OX3 7LD
she/her
Loren Kell
DPhil (Oxon), BSc (Hons)
Postdoctoral Researcher in Translational Immunology
I am a postdoctoral researcher in the Translational Pharmacology (Fullerton) Group at the Botnar Institute. I am mainly interested in understanding differences in human immunity based on sex and biological ageing. Following my undergraduate degree at University College London, I obtained my DPhil/PhD from Oriel College, Oxford, where I worked on describing the geroprotective effects of mTOR inhibitors on immune DNA damage with Ghada Alsaleh, Lynne Cox, and Katja Simon. In my current role, I am leveraging human immune challenge models using the KLH neoantigen to explore the generation of resident memory T cells.
Recent publications
Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage.
Journal article
Kell L. et al, (2026), Aging Cell, 25
Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system.
Journal article
Nunes M. et al, (2026), Cell Death Dis, 17
The roles of placental senescence, autophagy and senotherapeutics in the development and prevention of pre-eclampsia: A focus on ergothioneine.
Journal article
Kell DB. et al, (2025), J Reprod Immunol, 171
Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage
Preprint
Kell L. et al, (2025)
Spermidine Mitigates Immune Cell Senescence, Enhances Autophagy, and Boosts Vaccine Responses in Healthy Older Adults.
Preprint
Alsaleh G. et al, (2025)
Overcoming immunosenescence: strategies to modulate DNA damage and senescence in immune cells and fibroblasts
Thesis / Dissertation
Kell L., (2024)
B0124 DIMETHYL FUMARATE MODULATES T CELL METABOLISM AND FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENT SAMPLES
Conference paper
Kell L. et al, (2023), Annals of the Rheumatic Diseases, 82, 1241 - 1241
The central role of DNA damage in immunosenescence.
Journal article
Kell L. et al, (2023), Front Aging, 4
Disparity in peripheral and renal B-cell depletion with rituximab in systemic lupus erythematosus: an opportunity for obinutuzumab?
Journal article
Reddy VR. et al, (2022), Rheumatology (Oxford), 61, 2894 - 2904
Mutational and phenotypic characterization of hereditary hemorrhagic telangiectasia.
Journal article
Shovlin CL. et al, (2020), Blood, 136, 1907 - 1918