Postdoctoral Research Fellow - Marie Curie IF
From Brazil to Oxford via Switzerland. Mariana's first steps as an immunologist started in Brazil while studying antimicrobial responses in shrimps and oysters during her BSc studies (2005-2010), for which she was awarded the University Medal. She then jumped into a completely new field, and dedicated her Master studies (2010-2012) to understand how the unfolded protein response in lymphocytes and monocytes is impacted by HIV infection and antiretroviral therapies. Close to completing her studies in the Federal University of Santa Catarina (UFSC), she got a permanent position as a lecturer in the same institution, where she taught Biology for 3 years.
To pursue a career as a scientist, she gave up the life-long stability of her job, and moved to Switzerland, where she did her PhD in Immunology at ETH, under the supervision of Prof. Annette Oxenius. There Mariana was very successful to bring new insights into how asymmetric cell division, a very conserved mechanism to generate diversity, impacts T cell fate as a requirement for the establishment of memory. She was the first to describe that effector and terminally exhausted CD8+ T cells lose their ability to undergo asymmetric mitoses, showing that asymmetric cell division is a feature of cells that retain stemness. Beyond that, she developed a strategy to boost asymmetric cell division in CD8+ T cells by transient inhibition of mTOR, which proved to be highly efficient to benefit memory formation - a potential new translational strategy to improve immune responses, especially in the context of chronic infections, tumours and ageing. For her PhD work, she was awarded the prestigious ETH Silver Medal.
Now in Oxford, Mariana joined the group of Prof. Katja Simon, and will use her previous expertise in the boundary between cell biology and immunology to further investigate how autophagy impacts the balance between stemness and differentiation in immunity and haematopoiesis. To develop this work, she was awarded fellowships from the Swiss National Science Foundation, Marie Skłodowska-Curie Actions and Wellcome Trust.
Getting to the (germinal) centre of SARS-CoV-2.
Richter FC. and Borsa M., (2020), Nat rev immunol
Borsa M. and Simon AK., (2020), Science, 369, 373 - 374
Landornamides: Antiviral Ornithine-Containing Ribosomal Peptides Discovered through Genome Mining.
Bösch NM. et al, (2020), Angew chem int ed engl, 59, 11763 - 11768
Chronic viral infections impinge on naive bystander CD8 T cells.
Barnstorf I. et al, (2020), Immun inflamm dis
LCMV-specific CD4 T cell dependent polyclonal B-cell activation upon persistent viral infection is short lived and extrafollicular.
Greczmiel U. et al, (2020), Eur j immunol, 50, 396 - 403