Contact information

Email	tal.arnon@kennedy.ox.ac.uk
Tel	+44 (0)1865 612648

My connections

Arnon Group | Humoral Immune Response Research Group, Kennedy Institute

Arnon Group | Humoral Immune Response Research Group

Tal Arnon

PhD

Kennedy Trust of Rheumatology Research (KTRR) Senior Research Fellow

My PhD, at the Hebrew University of Jerusalem with Professor Ofer Mandelboim, focused on understanding how human natural killer cells recognize and eliminate virally infected cells.

As a postdoctoral fellow, in the University of California San Francisco with Professor Jason Cyster, I moved on to investigate mechanisms that regulate lymphocytes trafficking in vivo.

By developing advanced imaging methods using 2-photon microscopy our studies helped to understand the importance of specialized niches within the spleen in regulating immune cell migration and function.

In January 2014, I joined the Kennedy Institute as a Senior Research Fellow. In our current work, we continue to explore the unique features of splenic immune responses, focusing on the roles of specialized subsets of macrophages and innate immune cells in regulation of B cell behaviour.

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Reboldi A. et al, (2016), Science (New York, N.Y.), 352
Correction: harnessing soluble NK cell killer receptors for the generation of novel cancer immune therapy.
Arnon TI. et al, (2015), PloS one, 10
Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen.
Arnon TI. and Cyster JG., (2014), Current topics in microbiology and immunology, 378, 107 - 128
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress.
Arnon TI. et al, (2013), Nature, 493, 684 - 688
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Arnon TI. et al, (2011), Science (New York, N.Y.), 333, 1898 - 1903
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.
Muppidi JR. et al, (2011), The Journal of experimental medicine, 208, 1941 - 1948
The crystal structure of CHIR-AB1: a primordial avian classical Fc receptor.
Arnon TI. et al, (2008), Journal of molecular biology, 381, 1012 - 1024
Harnessing soluble NK cell killer receptors for the generation of novel cancer immune therapy.
Arnon TI. et al, (2008), PloS one, 3
Tumor and viral recognition by natural killer cells receptors.
Arnon TI. et al, (2006), Seminars in cancer biology, 16, 348 - 358
Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1.
Gazit R. et al, (2006), Nature immunology, 7, 517 - 523
The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and beta 2-microglobulin-free HLA-G molecules.
Gonen-Gross T. et al, (2005), Journal of immunology (Baltimore, Md. : 1950), 175, 4866 - 4874
Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.
Stern N. et al, (2005), Journal of immunology (Baltimore, Md. : 1950), 174, 6692 - 6701
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.
Arnon TI. et al, (2005), Nature immunology, 6, 515 - 523
MHC class I-independent recognition of NK-activating receptor KIR2DS4.
Katz G. et al, (2004), Journal of immunology (Baltimore, Md. : 1950), 173, 1819 - 1825
The mechanisms controlling NK cell autoreactivity in TAP2-deficient patients.
Markel G. et al, (2004), Blood, 103, 1770 - 1778
The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.
Arnon TI. et al, (2004), Blood, 103, 664 - 672
Enhanced recognition of human NK receptors after influenza virus infection.
Achdout H. et al, (2003), Journal of immunology (Baltimore, Md. : 1950), 171, 915 - 923
CD66a interactions between human melanoma and NK cells: a novel class I MHC-independent inhibitory mechanism of cytotoxicity.
Markel G. et al, (2002), Journal of immunology (Baltimore, Md. : 1950), 168, 2803 - 2810
Recognition of viral hemagglutinins by NKp44 but not by NKp30.
Arnon TI. et al, (2001), European journal of immunology, 31, 2680 - 2689
Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail number 4.
Katz G. et al, (2001), Journal of immunology (Baltimore, Md. : 1950), 166, 7260 - 7267
Recognition of haemagglutinins on virus-infected cells by NKp46 activates lysis by human NK cells.
Mandelboim O. et al, (2001), Nature, 409, 1055 - 1060

Key Publications

Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress.
Arnon TI. et al, (2013), Nature, 493, 684 - 688
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Arnon TI. et al, (2011), Science (New York, N.Y.), 333, 1898 - 1903
Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone.
Muppidi JR. et al, (2011), The Journal of experimental medicine, 208, 1941 - 1948
Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.
Arnon TI. et al, (2005), Nature immunology, 6, 515 - 523

Recent Publications

IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Reboldi A. et al, (2016), Science (New York, N.Y.), 352
Correction: harnessing soluble NK cell killer receptors for the generation of novel cancer immune therapy.
Arnon TI. et al, (2015), PloS one, 10
Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen.
Arnon TI. and Cyster JG., (2014), Current topics in microbiology and immunology, 378, 107 - 128
Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress.
Arnon TI. et al, (2013), Nature, 493, 684 - 688
GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood.
Arnon TI. et al, (2011), Science (New York, N.Y.), 333, 1898 - 1903

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