Tal Arnon
PhD
Associated Professor
My PhD, at the Hebrew University of Jerusalem with Professor Ofer Mandelboim, focused on understanding how human natural killer cells recognize and eliminate virally infected cells.
As a postdoctoral fellow, in the University of California San Francisco with Professor Jason Cyster, I moved on to investigate mechanisms that regulate lymphocytes trafficking in vivo.
By developing advanced imaging methods using 2-photon microscopy our studies helped to understand the importance of specialized niches within the spleen in regulating immune cell migration and function.
In January 2014, I joined the Kennedy Institute as a Senior Research Fellow. In our current work, we continue to explore the unique features of splenic immune responses, focusing on the roles of specialized subsets of macrophages and innate immune cells in regulation of B cell behaviour.
Recent publications
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Marginal zone SIGN-R1+ macrophages are essential for the maturation of germinal center B cells in the spleen.
Journal article
Pirgova G. et al, (2020), Proc natl acad sci u s a, 117, 12295 - 12305
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Visualization of T Cell Migration in the Spleen Reveals a Network of Perivascular Pathways that Guide Entry into T Zones.
Journal article
Chauveau A. et al, (2020), Immunity, 52, 794 - 807.e7
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IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches.
Journal article
Reboldi A. et al, (2016), Science, 352
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Specialized Subsets of Tissue-Resident Macrophages in Secondary Lymphoid Organs
Chapter
Chauveau A. and Arnon TI., (2016), Encyclopedia of Cell Biology, 759 - 769
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Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen.
Journal article
Arnon TI. and Cyster JG., (2014), Curr top microbiol immunol, 378, 107 - 128