Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

International expert working group develop first pre-guidelines for conducting robust studies aimed at prevention of osteoarthritis (OA) after acute knee injury.

The working group, convened by researchers from the universities of Oxford, Leeds and Cardiff developed a set of considerations on the design and conduct of interventional studies which aim to prevent OA in patients who have had an acute knee injury. These considerations are intended to underpin future guidelines as the field evolves.

Joint injury is one of the biggest risk factors for OA, with 50% of people with significant knee injuries developing what is called post-traumatic OA (PTOA) within 10 years.

"Prevention of OA is as crucial as developing new therapies for established osteoarthritis", says research co-lead Dr Fiona Watt, at the Arthritis Research UK Centre for Osteoarthritis Pathogenesis, Kennedy Institute, University of Oxford. "We were able to bring together a team of experts from diverse areas, from fundamental science to clinical trialists and the pharmaceutical industry, to focus on improving our research approach to testing new treatments at the time of a joint injury, with a view of improving healthcare."

Currently, there are no specific guidelines for clinical trials measuring the effect of interventions for OA prevention after injury, with this type of study presenting a number of particular challenges. These include the window of opportunity for any given intervention and the potential duration of study needed for meaningful results meaning that earlier 'surrogate' outcomes will be important.

The initial considerations identified by the group include information on who should be included in such trials, timing of intervention, what outcomes should be collected and at what times, the importance of comparators including placebo treatments and the importance of linking with pre-clinical models of joint injury and human cohort studies to inform future design of studies. Critical knowledge gaps and areas for future research have been highlighted as part of this work.

"Exciting advances in preclinical studies indicate that intervention at the time of injury could reduce or delay PTOA" says co-lead Deborah Mason from Cardiff University. "This paper is important as it starts to provide a pathway towards testing such treatments in human clinical trials."

The team concluded that if we are to improve care and deliver new therapeutics which benefit patients, progress in the field of OA prevention is urgently required, in spite of its challenges.

The research was funded by Arthritis Research UK.

FUNDER

ArthritisResearch_HZ_RGB_Logo_300dpi.jpg

Similar stories

NDORMS researchers awarded for Dupuytren research

Awards Hand Kennedy Main

Three NDORMS researchers have received awards from the International Dupuytren Society, a patient organisation that brings together Dupuytren Disease patient societies from across the world.

Hope for rheumatoid arthritis patients who are non-responsive to anti-TNF

Arthritis Kennedy Main

New research published in The Lancet shows that tocilizumab is a more effective treatment than rituximab for rheumatoid arthritis patients with a poor response to anti-tumour necrosis factor (TNF).

A new study maps the expression of innate immune receptors during the course of arthritis

Arthritis Kennedy Main

The research, which was a collaboration with researchers from Oxford University and Queen Mary University of London and published in Journal of Autoimmunity, looked at changes in receptors known as toll-like receptors (TLRs) in arthritis at different stages of disease.

International Women's Day

Department Main

It’s International Women's Day! This year’s theme is #Choosetochallenge. We’re celebrating some of the amazing women at NDORMS, and asking them what changes they’d like to see in medical sciences over the next 100 years.

Patients and carers invited to join new group helping to shape research and treatment of bones, muscles and joints

Main PPI

Oxford’s newest patient partner group, OPEN ARMS launches today to explore the causes, treatment and care for patients with musculoskeletal conditions. Its first three patient partners explain why they are involved and invite other members of the public to join the team.

NDORMS academics named NIHR Senior Investigators

Main

Congratulations to Professor Jonathan Rees who has been announced as a National Institute of Health Research (NIHR Senior Investigator).