Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A recent workshop at Pembroke College, Oxford, provided a showcase for research within the Arthritis Therapy Acceleration Programme (A-TAP) aimed at speeding up the delivery of new drugs for immune-mediated inflammatory disease (IMIDs).

A-TAP logo

The workshop was organised by the Kennedy Institute’s Director of Clinical Research and A-TAP lead, Prof Chris Buckley, to raise awareness of A-TAP and the funding opportunities it provides to support experimental medicine studies.

In opening remarks, Chris highlighted the importance of experimental medicine to overcome barriers in drug discovery. He explains, “Developments in our understanding of the genetic and cellular basis of disease have revealed that diseases traditionally classified as anatomically distinct share much more in common that previously recognized. Coupled with advances in biologic and cellular therapy and innovations in clinical trial design, it is now possible to run trials that have pathology-based outcome measures with one drug being studies across a ‘basket’ of different IMIDs”.

A-TAP was launched by the Universities of Oxford and Birmingham in 2017 to apply this new approach to trial design for development of novel treatments based on the underlying causes of inflammatory disease. The programme is supported by a £7M award from the Kennedy Trust for Rheumatology Research.

One way in which A-TAP facilitates clinical studies is to improve access to patients and diseased tissue samples. During the workshop, Dr Andrew Filer, an A-TAP investigator at the University of Birmingham, described his work on the Birmingham Early Arthritis Cohort (BEACON) to biopsy joint tissues when patients first show signs of inflammation in their joints. This approach is enabling research across the A-TAP network into early predictors and drivers of arthritis.

Robust and accurate tools to measure biological markers in tissues are also crucial to understand disease processes and how they are affected by drugs. Led by Dr Clare Verrill, University of Oxford, workshop participants also learned about the application of artificial intelligence approaches to measure pathology based markers across tissue samples from different types of inflammatory disease.

The workshop also gave a flavour of two new clinical studies enabled by A-TAP. These are exploring the effect of anti TNF therapy on tissue based markers in Rheumatoid Arthritis and Inflammatory bowel disease as well as the effect of three different biological therapies on cell populations in patients with ankylosing spondylitis

For more information about A-TAP and funding opportunities for Oxford and Birmingham based projects in the area of inflammatory arthritis, please contact A-TAP Operations Manager, Dr Claire Potter.

 

Similar stories

NIHR Fellowships awarded to NDORMS researchers

Congratulations to Eileen Morrow and Mae Chester-Jones who have received NIHR Doctoral Fellowships

ORUK Early Career Research Fellowship awarded to NDORMS researcher

Congratulations to Jack Tu who has been awarded an Orthopaedic Research UK Early Career Research Fellowship to explore the cause of knee pain after total knee replacement.

OCTRU - delivering answers to important clinical questions

The Oxford Clinical Trials Research Unit (OCTRU) has received NIHR benchmarking results and offers excellent value for money according to the report

Unhelpful thoughts about fracture symptoms hinder recovery

The importance of mindsets and feelings about fracture symptoms have been shown to be a key factor in recovery of musculoskeletal conditions.

Fat tissues can play a protective role against inflammation in the intestine

A new study in The EMBO Journal has revealed how fat tissues might provide a protective role in intestinal inflammation opening new lines of research into the treatment of inflammatory bowel diseases.

NDORMS researchers awarded Sir Henry Wellcome Fellowships

Kennedy Institute researchers Mariana Borsa and Edward Jenkins have both been awarded Sir Henry Wellcome Postdoctoral Fellowships, which give recently qualified postdoctoral researchers the opportunity to start independent research careers.