Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Immunohistochemical studies have confirmed the innervation of bone with neuropeptidergic neurons containing vasoactive intestinal polypeptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP). In this study, we report effects of VIP on connective tissue cell metabolism. VIP stimulated PGE2 production in human articular chondrocytes, human osteoblast-like cells and human synovial cells, however, stromelysin production was unaffected. VIP also stimulated cAMP production in human osteoblast-like cells, but not in human articular chondrocytes or synovial cells. These findings are suggestive of a role of VIP in connective tissue cell metabolism which may contribute to the inflammatory processes of arthritis.

Original publication

DOI

10.1016/0167-0115(92)90660-m

Type

Journal article

Journal

Regul pept

Publication Date

23/01/1992

Volume

37

Pages

111 - 121

Keywords

Cartilage, Articular, Connective Tissue, Cyclic AMP, Dinoprostone, Humans, In Vitro Techniques, Matrix Metalloproteinase 3, Metalloendopeptidases, Osteoblasts, Peptide Hydrolases, Synovial Membrane, Vasoactive Intestinal Peptide