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Immunohistochemical studies have confirmed the innervation of bone with neuropeptidergic neurons containing vasoactive intestinal polypeptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP). In this study, we report effects of VIP on connective tissue cell metabolism. VIP stimulated PGE2 production in human articular chondrocytes, human osteoblast-like cells and human synovial cells, however, stromelysin production was unaffected. VIP also stimulated cAMP production in human osteoblast-like cells, but not in human articular chondrocytes or synovial cells. These findings are suggestive of a role of VIP in connective tissue cell metabolism which may contribute to the inflammatory processes of arthritis.

Original publication




Journal article


Regul pept

Publication Date





111 - 121


Cartilage, Articular, Connective Tissue, Cyclic AMP, Dinoprostone, Humans, In Vitro Techniques, Matrix Metalloproteinase 3, Metalloendopeptidases, Osteoblasts, Peptide Hydrolases, Synovial Membrane, Vasoactive Intestinal Peptide