Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.
Pointon JJ., Chapman K., Harvey D., Sims AM., Bradbury L., Laiho K., Kauppi M., Kaarela K., Tuomilehto J., Brown MA., Wordsworth BP.
To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.CD14 and TLR4 showed an association with AS in the Finns only.