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OBJECTIVE: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS). METHODS: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed. RESULTS: In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses. CONCLUSION: CD14 and TLR4 showed an association with AS in the Finns only.

Type

Journal article

Journal

The Journal of rheumatology

Publication Date

08/2008

Volume

35

Pages

1609 - 1612

Addresses

NIHR OxfordMusculoskeletal Biomedical Research Unit and BotnarResearch Centre, Oxford, UK. jennyp@well.ox.ac.uk

Keywords

Humans, Spondylitis, Ankylosing, Genetic Predisposition to Disease, Antigens, CD14, Odds Ratio, Case-Control Studies, Cohort Studies, Polymorphism, Single Nucleotide, Finland, Great Britain, Female, Male, Toll-Like Receptor 4