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Using a panel of monoclonal antibodies against a variety of lymphoid and non-lymphoid antigens the immunohistological staining pattern of giant cells from a case of giant-cell tumour of bone has been compared with that of osteoclasts from the developing ends of fetal long bones. Only EBM-11, an antibody reacting with a wide spectrum of macrophages, stained both osteoclasts and giant cells; stromal cells and osteoblasts did not react. This indicates that osteoclasts and giant cells are phenotypically and presumably functionally similar. It is argued that the osteoclasts and the tumour-derived giant cells in bone are derived from a similar mononuclear precursor.

Original publication

DOI

10.1002/path.1711470302

Type

Journal article

Journal

The Journal of pathology

Publication Date

11/1985

Volume

147

Pages

153 - 158

Keywords

Macrophages, Osteoclasts, Fetus, Humans, Giant Cell Tumors, Bone Neoplasms, Antibodies, Monoclonal, Cell Differentiation, Adult, Female