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A multi-centre, double-blind, crossover study was carried out in 80 patients with rheumatoid arthritis to compare the efficacy and side-effect profiles of two formulations of indomethacin. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times a day for a period of 4 weeks before being crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by both investigator and patient indicated that controlled-release indomethacin tablets, 75 mg given at night, was as efficacous as immediate-release indomethacin capsules given 3-times daily. However, the controlled-release formulation had a superior side-effect profile with a reduced incidence of abdominal/epigastric pain compared to the immediate-release preparation.

Original publication

DOI

10.1185/03007999009110480

Type

Journal article

Journal

Current medical research and opinion

Publication Date

01/1990

Volume

12

Pages

121 - 127

Addresses

Queen Elizabeth Hospital, Birmingham, England.

Keywords

Humans, Arthritis, Rheumatoid, Indomethacin, Capsules, Delayed-Action Preparations, Tablets, Pain Measurement, Administration, Oral, Drug Administration Schedule, Double-Blind Method, Adult, Aged, Middle Aged, Female, Male, Multicenter Studies as Topic, Randomized Controlled Trials as Topic