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The use of osteogenic stem cells or osteoprogenitors to reconstruct skeletal tissues is a popular area of research investigation with high potential for successful use of tissue-engineering principles in orthopedics. Recent studies demonstrate the migration of marrow-derived stem cells to skeletal sites and the proliferation and differentiation at local tissue sites and support possibilities for assessing the successful uses of human osteoprogenitors in the treatment of bone deficiency diseases. In addition, the development of gene therapy procedures in these and other conditions is now considered an achievable goal with the use of these primitive marrow cells.

Original publication




Journal article


Journal of biomedical materials research

Publication Date





384 - 389


Bone Research Laboratory, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, Oxon., OX3 7LD, United Kingdom.


Bone and Bones, Stem Cells, Animals, Humans, Bone Diseases, Orthopedic Procedures, Tissue Engineering, Phenotype