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The progress in genome characterizations has opened new routes for studying enzyme families. The availability of the human genome enabled us to delineate the large family of short-chain dehydrogenase/reductase (SDR) members. Although the human genome releases are not yet final, we have already found 63 members. We have also compared these SDR forms with those of three model organisms: Caenorhabditis elegans, Drosophila melanogaster, and Arabidopsis thaliana. We detect eight SDR ortholog clusters in a cross-genome comparison. Four of these clusters represent extended SDR forms, a subgroup found in all life forms. The other four are classical SDRs with activities involved in cellular differentiation and signalling. We also find 18 SDR genes that are present only in the human genome of the four genomes studied, reflecting enzyme forms specific to mammals. Close to half of these gene products represent steroid dehydrogenases, emphasizing the regulatory importance of these enzymes.

Original publication

DOI

10.1110/ps.26902

Type

Journal article

Journal

Protein science : a publication of the Protein Society

Publication Date

03/2002

Volume

11

Pages

636 - 641

Addresses

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm, Sweden.

Keywords

Animals, Humans, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis, Oxidoreductases, Evolution, Molecular, Multigene Family, Genome, Genome, Human