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Although much remains to be learned about environmental factors and putative pathogens, significant strides have been made on the genetic front. Genes appear to have a greater role in determining disease severity than disease risk. In particular, patients who are heterozygous for two HLA-DR4 subtypes are prone to severe erosive disease, making them candidates for early, aggressive therapy.

Original publication

DOI

10.1080/21548331.1995.11443184

Type

Journal article

Journal

Hospital practice (Office ed.)

Publication Date

04/1995

Volume

30

Pages

77 - 81

Addresses

Institute of Molecular Medicine, University of Oxford, England.

Keywords

Humans, Arthritis, Rheumatoid, Autoimmune Diseases, Disease Susceptibility, HLA-DR4 Antigen, Environmental Health, Genes, MHC Class II, Haplotypes, Heterozygote, Alleles, Female, Male