Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Although much remains to be learned about environmental factors and putative pathogens, significant strides have been made on the genetic front. Genes appear to have a greater role in determining disease severity than disease risk. In particular, patients who are heterozygous for two HLA-DR4 subtypes are prone to severe erosive disease, making them candidates for early, aggressive therapy.


Journal article


Hosp pract (off ed)

Publication Date





77 - 81


Alleles, Arthritis, Rheumatoid, Autoimmune Diseases, Disease Susceptibility, Environmental Health, Female, Genes, MHC Class II, HLA-DR4 Antigen, Haplotypes, Heterozygote, Humans, Male