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Xenografts of human osteosarcoma growing in athymic mice are inhibited in growth rate by human interferon-alpha (IFN-alpha) treatment. In addition, differentiation of trabecular bone occurs external to the osteosarcomatous tissue and this is entirely dependent on IFN treatment. We have used species-specific anticollagens and antivimentin antibodies to determine the species origins of this trabecular bone. By using immunohistochemical procedures, it was found that this bone is host-derived. These results suggest that IFN provoked the production of a bone-inducing agent by the human osteosarcomas.

Original publication

DOI

10.3109/03008208909002414

Type

Journal article

Journal

Connective tissue research

Publication Date

01/1989

Volume

23

Pages

145 - 151

Addresses

Nuffield Department of Orthopaedic Surgery, University of Oxford, UK.

Keywords

Tumor Cells, Cultured, Animals, Mice, Inbred BALB C, Mice, Mice, Nude, Osteosarcoma, Collagen, Interferons, Immunohistochemistry, Species Specificity, Osteogenesis, Female