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Xenografts of human osteosarcoma growing in athymic mice are inhibited in growth rate by human interferon-alpha (IFN-alpha) treatment. In addition, differentiation of trabecular bone occurs external to the osteosarcomatous tissue and this is entirely dependent on IFN treatment. We have used species-specific anticollagens and antivimentin antibodies to determine the species origins of this trabecular bone. By using immunohistochemical procedures, it was found that this bone is host-derived. These results suggest that IFN provoked the production of a bone-inducing agent by the human osteosarcomas.

Type

Journal article

Journal

Connect tissue res

Publication Date

1989

Volume

23

Pages

145 - 151

Keywords

Animals, Collagen, Female, Immunohistochemistry, Interferons, Mice, Mice, Inbred BALB C, Mice, Nude, Osteogenesis, Osteosarcoma, Species Specificity, Tumor Cells, Cultured