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We performed a case-control study of polymorphisms of glutathione S-transferase (GST) isoenzymes and manganese superoxide dismutase (MnSOD) in black South Africans with systemic sclerosis (SSc). The frequency of the GSTM1*B phenotype was significantly decreased in the overall SSc group compared with controls (OR=0.19, p(corr)<.05), implying a possible protective effect against development of the disease. There was also a trend toward increased MnSODAla allele and phenotype frequencies in the diffuse cutaneous SSc subset compared with controls (OR=2.11 and 3.15, respectively, p(corr)<.1). Our findings provide new data on the distribution of GST and MnSOD polymorphisms in healthy Africans and further evidence that genetic factors may have a contributory role to play in predisposing to oxidative stress in SSc.

Original publication

DOI

10.1016/j.freeradbiomed.2004.02.079

Type

Journal article

Journal

Free Radic Biol Med

Publication Date

01/06/2004

Volume

36

Pages

1403 - 1407

Keywords

Alleles, Case-Control Studies, Female, Free Radical Scavengers, Glutathione Transferase, Humans, Male, Oxygen, Phenotype, Polymorphism, Genetic, Scleroderma, Systemic, Superoxide Dismutase