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BACKGROUND: Prior research on accelerated knee osteoarthritis (AKOA) was primarily confined to the Osteoarthritis Initiative, which was enriched with people with risk factors for knee osteoarthritis (KOA). It is unclear how often AKOA develops in a community-based cohort and whether we can replicate prior findings from the Osteoarthritis Initiative in another cohort. Hence, we determined the incidence and characteristics of AKOA among women in the Chingford Study, which is a prospective community-based cohort. METHODS: The Chingford Study had 1003 women with quinquennial knee radiographs over 15 years. We divided the 15-year observation period into three consecutive 5-year phases. Within each 5-year phase, we selected 3 groups of participants among women who started a phase without KOA (Kellgren-Lawrence [KL]  1 in 7 women with incident KOA had AKOA. Like the Osteoarthritis Initiative, people with AKOA were more likely to have greater age and BMI.

Original publication




Journal article


Bmc musculoskelet disord

Publication Date





Epidemiology, Phenotype, Total knee replacement, Age Factors, Arthroplasty, Replacement, Knee, Body Mass Index, Disease Progression, Female, Follow-Up Studies, Humans, Incidence, Knee Joint, London, Middle Aged, Osteoarthritis, Knee, Prospective Studies, Radiography, Risk Factors, Self Report