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While twin studies have previously demonstrated high heritability of susceptibility to ankylosing spondylitis (AS), it is only recently that the involvement of genetic factors in determining the severity of the disease has been demonstrated. The genes involved in determining the rate of ankylosis in AS are likely to be different from those involved in the underlying immunologic events, and represent important potential targets for treatment of AS. This article will describe the progress that has been made in the genetic epidemiology of AS, and in identifying the genes involved.

Original publication

DOI

10.1097/00002281-200207000-00004

Type

Journal article

Journal

Current opinion in rheumatology

Publication Date

07/2002

Volume

14

Pages

354 - 360

Addresses

Wellcome Trust Center for Human Genetics, Spondyloarthritis and Bone Disease Research Group, Headington, UK. mbrown@well.ox.ac.uk

Keywords

Humans, Spondylitis, Ankylosing, Genetic Predisposition to Disease, Diseases in Twins, Chromosome Mapping, Gene Expression, Molecular Epidemiology