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The growth of human osteosarcoma xenografts in nude mice can be inhibited by human interferon-alpha (IFN-alpha). Histologic examination of growth-inhibited tumors has revealed mineralization and partial replacement of the tumor by normal bone tissue. We have investigated whether the normal bone tissue was formed by differentiated tumor cells or by induction of host stroma to differentiate into bone tissue. Employing antibodies to both murine and human type I collagen, it was found that the normal bone produced in IFN-inhibited osteosarcomas was host derived. These results suggest that IFN induced the osteosarcoma cells to produce a bone-inductive agent that interacts with the host cells, and leads to the formation of mature normal bone tissue in a heterotopic site.

Original publication

DOI

10.1002/jbmr.5650030212

Type

Journal article

Journal

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Publication Date

04/1988

Volume

3

Pages

199 - 202

Addresses

MRC Bone Research Laboratory, Nuffield Department of Orthopaedic Surgery, University of Oxford, UK.

Keywords

Bone and Bones, Cell Line, Animals, Humans, Mice, Mice, Nude, Osteosarcoma, Interferon Type I, Transplantation, Heterologous, Neoplasm Transplantation, Female