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The role of germline polymorphisms of the T-cell receptor A/D and B loci in susceptibility to ankylosing spondylitis was investigated by linkage studies using microsatellite markers in 215 affected sibling pairs. The presence of a significant susceptibility gene (lambda > or = 1.6) at the TCRA/D locus was excluded (LOD score < -2.0). At the TCRB locus, there was weak evidence of the presence of a susceptibility gene (P = 0.01, LOD score 1.1). Further family studies will be required to determine whether this is a true or false-positive finding. It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis.

Type

Journal article

Journal

British journal of rheumatology

Publication Date

04/1998

Volume

37

Pages

454 - 458

Addresses

Wellcome Trust Centre for Human Genetics, Headington, Oxford.

Keywords

Humans, Spondylitis, Ankylosing, Receptors, Antigen, T-Cell, Nuclear Family, Microsatellite Repeats, Genetic Heterogeneity, Germ-Line Mutation, Polymorphism, Genetic, Family Health, Female, Male, Genetic Linkage