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Rheumatoid arthritis is often considered to be an autoimmune disease in which the abnormal immunological response is triggered by an infectious agent(s) but progress towards identifying such extrinsic factors has so far been unrevealing. In contrast, the genetic component of host susceptibility is slowly becoming clearer. In particular, the nature of the HLA class II association with the disease has led to new insights into its pathogenesis and possible novel forms of therapy.

Original publication

DOI

10.1016/0952-7915(92)90059-n

Type

Journal article

Journal

Current opinion in immunology

Publication Date

12/1992

Volume

4

Pages

766 - 769

Addresses

Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.

Keywords

Humans, Arthritis, Rheumatoid, Genetic Predisposition to Disease, Rheumatoid Factor, HLA-D Antigens, Chromosome Mapping