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OBJECTIVE: To assess the genetic association between secretor status and ankylosing spondylitis (AS). METHODS: A restriction digest method for determining secretor status was developed; 166 patients with AS and 216 healthy British white controls were typed for secretor status using this method. RESULTS: The frequency of nonsecretors among patients with AS (47/166, 28%) was not significantly different from controls (72/216, 33%). CONCLUSION: Secretor status does not influence susceptibility to AS.

Type

Journal article

Journal

The Journal of rheumatology

Publication Date

02/1998

Volume

25

Pages

318 - 319

Addresses

Wellcome Trust Centre for Human Genetics, Oxford, UK.

Keywords

Humans, Spondylitis, Ankylosing, Fucosyltransferases, Cohort Studies, Immunity, Mucosal