Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The primary systemic vasculitides are a group of autoimmune conditions characterised by occlusion, stenosis or aneurysmal dilatation of blood vessels secondary to intra-mural inflammation. Current therapy has converted the outlook of these diseases from death or severe morbidity to a remitting-relapsing condition in most instances. Longer survival, relapsing course of disease and chronic glucocorticoid therapy probably contribute to an increase in cardiovascular events and morbidity. This article reviews the available data for effect of primary systemic vasculitis on cardiovascular end points like coronary artery disease, congestive cardiac failure, hypertension and aortic aneurysm in all age groups. We examine the interplay between the activated endothelium, autoimmune mechanisms and treatment factors to produce a direct insult or increased atherogenic potential of primary systemic vasculitis. Recommendations to deal with cardiovascular end points are made.

Original publication

DOI

10.1016/j.berh.2009.02.002

Type

Journal article

Journal

Best practice & research. Clinical rheumatology

Publication Date

06/2009

Volume

23

Pages

419 - 428

Addresses

Rheumatology Department, University of Oxford, Oxford, UK.

Keywords

Humans, Cardiovascular Diseases, Aortic Aneurysm, Hypertension, Vasculitis, Survival Rate, Adolescent, Child, Child, Preschool, Female, Male, Coronary Artery Disease, Heart Failure, Young Adult