Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Pyrophosphate and diphosphonates produce striking results on calcium metabolism in experimental animals and man. Compounds containing P-O-P- bonds (e.g. inorganic pyrophosphate [PP-ii1 or P-C-P bonds (diphosponates) inhibit both the formation and dissolution of calcium phosphate crystals in vitro. PP-i may have a physiological function in regulating calcification and bone turnover, and obnormalities in its metabolism may occur in some human diseases notably hypophosphatasia and pseudogout. Diphosphonates inhibit ectopic calcification, and slow down resorption and bone turnover in several experimental systems in vivo. They have helped in studies of various aspects of the regulation of calcium metabolism. The diphosphonate, disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) has been shown in clinical studies to be effective against ectopic calcification particularly in myositis ossificans progressiva and in disorders of increased bone resorption such as Paget's diseases and some types of osteoporosis. -99mTechnetium complexes of EHDP, PP-i and other polyphosphates have also recently been used successfully as bone scanning agents.

Original publication

DOI

10.1097/00003086-197505000-00038

Type

Journal article

Journal

Clin orthop relat res

Publication Date

05/1975

Pages

241 - 263

Keywords

Animals, Bone Resorption, Bone and Bones, Calcification, Physiologic, Calcinosis, Calcium, Calcium Metabolism Disorders, Cartilage, Chemical Phenomena, Chemistry, Culture Techniques, Depression, Chemical, Diphosphates, Etidronic Acid, Humans, Hydroxyapatites, Kidney Diseases, Methylene Chloride, Organophosphonates, Organophosphorus Compounds, Osteoporosis, Urinary Bladder Calculi, Vitamin D