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Since several metabolites and analogues of vitamin D have become available, their physiological and therapeutic potential have been studied in various disorders of mineral metabolism, particularly those classically termed vitamin D-resistant. In some instances this resistance appears to be due to defective metabolism of vitamin D or to defective target organ responses, but in others it is not. Although the precise effect of vitamin D or its metabolites on mineralization of bone is still unknown there is some evidence that the metabolites differ in their relative effects on intestine, bone, muscle and parathyroid glands. These differences may eventually have therapeutic value. At present the major advantage of 1alpha-hydroxylated derivatives of vitamin D over other compounds resides in their more rapid onset and reversal of action which makes them much easier and safer to use.

Original publication

DOI

10.1111/j.1365-2265.1977.tb03381.x

Type

Journal article

Journal

Clinical endocrinology

Publication Date

12/1977

Volume

7 Suppl

Pages

191s - 201s

Keywords

Bone and Bones, Humans, Bone Resorption, Kidney Failure, Chronic, Metabolism, Inborn Errors, Hypercalcemia, Hydroxycholecalciferols, Vitamin D, Drug Resistance, Chronic Kidney Disease-Mineral and Bone Disorder