Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A panel of healthy volunteers was screened by bronchial histamine provocation. The response used was the flow rate achieved during a partial forced expiratory manoeuvre at a lung volume 30% of the vital capacity above the residual volume. Those subjects who were relatively sensitive to the bronchoconstrictor effects of inhaled histamine took part in a reproducibility study. Those with consistent responses took part in a further study in which the bronchodilator, and bronchoconstriction-protective, effects of orally administered chlorpheniramine, terfenadine and salbutamol were investigated. The technique was able to demonstrate the efficacy of these drugs in non-patient volunteers. Thus it seems to be a suitable method for the early evaluation, in man, of certain drugs with an anti-asthma therapeutic potential. It also provides useful information on the dose and duration of action of compounds prior to the first efficacy trials in patients.

Original publication

DOI

10.1007/978-3-0348-9156-1_22

Type

Journal article

Journal

Agents and actions. supplements

Publication Date

01/1988

Volume

23

Pages

285 - 289

Addresses

Beecham Pharmaceuticals Research Division, Great Burgh, Epsom, Surrey, U.K.

Keywords

Bronchi, Humans, Histamine, Bronchodilator Agents, Bronchial Provocation Tests, Forced Expiratory Flow Rates, Forced Expiratory Volume, Administration, Oral, Drug Evaluation