Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction.
Toor IS., Rückerl D., Mair I., Ainsworth R., Meloni M., Spiroski A-M., Benezech C., Felton JM., Thomson A., Caporali A., Keeble T., Tang KH., Rossi AG., Newby DE., Allen JE., Gray GA.
In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.