Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes - a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field.

Original publication

DOI

10.1038/nrd.2016.39

Type

Journal article

Journal

Nat rev drug discov

Publication Date

08/2016

Volume

15

Pages

551 - 567

Keywords

Animals, Anti-Inflammatory Agents, Disease Models, Animal, Humans, Inflammation, Inflammation Mediators, Mice, Rats, Signal Transduction, Zebrafish