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Prostate cancer is a high-incidence cancer that requires improved patient stratification to ensure accurate predictions of risk and treatment response. Due to the significant contributions of transcription factors and epigenetic regulators to prostate cancer progression, there has been considerable progress made in developing gene signatures that may achieve this. Some of these are aligned to activities of key drivers such as the androgen receptor, whilst others are more agnostic. In this review, we present an overview of these signatures, the strategies for their derivation, and future perspectives on their continued development and evolution.

Original publication




Journal article


Cancers (basel)

Publication Date





biobanking, biomarkers, chromatin, computational biology, epigenetics, prognostication, prostate cancer, signatures, stratification, transcription factors