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With continuous T cell receptor (TCR) signaling, T cells can attenuate subsequent antigen responses through adaptive tolerance, thus averting autoimmunity, but potentially also providing refuge to developing cancers. Elliot and coworkers add to our understanding of adaptation via immune checkpoints by exploiting accelerated in vivo adaptive tolerance in the face of strong TCR signaling.

Original publication

DOI

10.1016/j.it.2021.10.014

Type

Journal article

Journal

Trends immunol

Publication Date

09/11/2021