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Infections with Salmonella enterica serovars Typhi and Paratyphi A cause an estimated 14 million cases of enteric fever annually. Here, the controlled nature of challenge studies is exploited to identify genetic variants associated with enteric fever susceptibility. Human challenge participants were genotyped by Illumina OmniExpress-24 BeadChip array (n = 176) and/or transcriptionally profiled by RNA sequencing (n = 174). While the study was underpowered to detect any single nucleotide polymorphisms (SNPs) significant at the whole-genome level, two SNPs within CAPN14 and MIATNB were identified with P 

Original publication

DOI

10.1128/iai.00389-21

Type

Journal article

Journal

Infect immun

Publication Date

07/03/2022

Keywords

HLA antigens, Salmonella Typhi, genomics, single nucleotide polymorphism, transcriptome, typhoid fever, unfolded protein response