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Epidemiological studies suggest that poor growth during fetal life and infancy is associated with decreased bone mass in adulthood. However, theses observations have not, to date, been corroborated in animal models. To address this issue we evaluated the influence of maternal protein restriction on bone mass and growth plate morphology among the adult offspring, using a rat model. Maternal protein restriction resulted in a reduction in bone area and BMC, but not BMD, among the offspring in late adulthood. The widened epiphyseal growth plate in the protein-restricted offspring is compatible with the programming of cartilage and bone growth by maternal nutrition in early life.

Original publication

DOI

10.1007/s00223-001-2104-9

Type

Journal article

Journal

Calcified tissue international

Publication Date

12/2002

Volume

71

Pages

493 - 498

Addresses

The University Department of Orthopaedic Surgery, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

Keywords

Bone and Bones, Growth Plate, Femur, Tibia, Animals, Rats, Rats, Wistar, Prenatal Exposure Delayed Effects, Absorptiometry, Photon, Diet, Protein-Restricted, Bone Development, Pregnancy, Bone Density, Female, Male, Animal Nutritional Physiological Phenomena