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Aim: Cetuximab is used for the treatment of RAS wild-type metastatic colorectal cancer patients. Standard administration schedule is once a week; however, the bioequivalence of an every-other-week (EOW) schedule was demonstrated. Methods: We compared a base case scenario of 100% weekly administration to an EOW at 50 or 100%. Medical examinations, patient management and loss of productivity were considered. Results: Base case was estimated at €100.6 million versus €92.8 million and €84.9 million of EOW 50 and 100%, which showed a cost reduction of 8 and 16%, respectively. Indirect costs accounted for 65% in both scenarios. Conclusion: The adoption of an EOW administration schedule of cetuximab reduced direct and indirect costs substantially.

Original publication




Journal article


Future oncol

Publication Date





2107 - 2112


bi-monthly administration, budget impact, cetuximab, Antineoplastic Agents, Immunological, Cetuximab, Colorectal Neoplasms, Drug Administration Schedule, Female, Health Care Costs, Health Expenditures, Humans, Incidence, Male, Neoplasm Metastasis, Neoplasm Staging, Population Surveillance