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A T helper type 1 (Th1)-mediated colitis with similarities to inflammatory bowel disease in humans developed in severe combined immunodeficiency mice reconstituted with CD45RB(high) CD4+ splenic T cells and could be prevented by cotransfer of CD45RB(low) CD4+ T cells. Inhibition of this Th1 response by the CD45RB(low) T cell population could be reversed in vivo by an anti-transforming growth factor (TGF) beta antibody. Interleukin (IL) 4 was not required for either the differentiation of function of protective cells as CD45RB(low) CD4+ cells from IL-4-deficient mice were fully effective. These results identify a subpopulation of peripheral CD4+ cells and TGF-beta as critical components of the natural immune regulatory mechanism, which prevents the development of pathogenic Th1 responses in the gut, and suggests that this immunoregulatory population is distinct from Th2 cells.

Original publication




Journal article


The Journal of Experimental Medicine

Publication Date





2669 - 2674


DNAX Research Institute of Molecular and Cellular Biology Inc., Palo Alto 94304, USA.


Spleen, T-Lymphocytes, CD4-Positive T-Lymphocytes, Th1 Cells, Animals, Mice, Inbred BALB C, Humans, Mice, Mice, Mutant Strains, Mice, SCID, Colitis, Antigens, CD45, Transforming Growth Factor beta, Interleukin-4, Antibodies, Monoclonal, Flow Cytometry, Protein Tyrosine Phosphatase, Non-Receptor Type 1