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OBJECTIVES: This study was designed to investigate whether coronary computed tomography angiography assessments of coronary plaque might explain differences in the prognosis of men and women presenting with chest pain. BACKGROUND: Important sex differences exist in coronary artery disease. Women presenting with chest pain have different risk factors, symptoms, prevalence of coronary artery disease and prognosis compared to men. METHODS: Within a multicenter randomized controlled trial, we explored sex differences in stenosis, adverse plaque characteristics (positive remodeling, low-attenuation plaque, spotty calcification, or napkin ring sign) and quantitative assessment of total, calcified, noncalcified and low-attenuation plaque burden. RESULTS: Of the 1,769 participants who underwent coronary computed tomography angiography, 772 (43%) were female. Women were more likely to have normal coronary arteries and less likely to have adverse plaque characteristics (p 4% (41% vs. 59%; p 

Original publication




Journal article


Jacc cardiovasc imaging

Publication Date





1804 - 1814


computed tomography, computed tomography coronary angiography, coronary artery disease, quantitative plaque analysis, sex, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Myocardial Infarction, Plaque, Atherosclerotic, Predictive Value of Tests, Risk Factors