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Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone-specific protein osteocalcin (OCN) is an established marker of vascular smooth muscle cell (VSMC) osteochondrogenic transdifferentiation and a known regulator of glucose metabolism. However, the role of OCN in controlling arterial calcification is unclear. We hypothesized that OCN regulates calcification in VSMCs and sought to identify the underpinning signaling pathways. Immunohistochemistry revealed OCN co-localization with VSMC calcification in human calcified carotid artery plaques. Additionally, 3 mM phosphate treatment stimulated OCN mRNA expression in cultured VSMCs (1.72-fold, p

Original publication




Journal article


J bone miner res

Publication Date





357 - 367


ARTERIAL CALCIFICATION, OSTEOCALCIN, WNT SIGNALING, Animals, Cells, Cultured, Glucose, Mice, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Osteocalcin, Vascular Calcification, Wnt Signaling Pathway