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OBJECTIVES: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR). METHODS: 51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR. Obstructive CAD was defined as CTCA stenosis >50 % and CTP hypoperfusion, ICA stenosis >70 % or FFR <0.80. RESULTS: PET hyperaemic myocardial blood flow (MBF) was lower in obstructive than non-obstructive territories defined by ICA/FFR (1.76 (1.32-2.20) vs 3.11 (2.44-3.79) mL/(g/min), P 

Original publication




Journal article


Eur radiol

Publication Date





1114 - 1124


Angina, Angiography, Imaging, Ischaemia, Perfusion, Adenosine, Aged, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Exercise Test, Female, Fractional Flow Reserve, Myocardial, Humans, Male, Middle Aged, Myocardial Perfusion Imaging, Oxygen Radioisotopes, Positron-Emission Tomography, Predictive Value of Tests, Prospective Studies, Sensitivity and Specificity, Tomography, X-Ray Computed, Vasodilator Agents, Water