Computed tomography myocardial perfusion vs 15O-water positron emission tomography and fractional flow reserve.
Williams MC., Mirsadraee S., Dweck MR., Weir NW., Fletcher A., Lucatelli C., MacGillivray T., Golay SK., Cruden NL., Henriksen PA., Uren N., McKillop G., Lima JAC., Reid JH., van Beek EJR., Patel D., Newby DE.
OBJECTIVES: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with 15O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with fractional flow reserve (FFR). METHODS: 51 patients (63 (61-65) years, 80 % male) with known/suspected coronary artery disease (CAD) underwent 320-multidetector CTCA followed by "snapshot" adenosine stress CTP. Of these 22 underwent PET and 47 ICA/FFR. Obstructive CAD was defined as CTCA stenosis >50 % and CTP hypoperfusion, ICA stenosis >70 % or FFR <0.80. RESULTS: PET hyperaemic myocardial blood flow (MBF) was lower in obstructive than non-obstructive territories defined by ICA/FFR (1.76 (1.32-2.20) vs 3.11 (2.44-3.79) mL/(g/min), P