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BACKGROUND: Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) can detect tissue-resident macrophage activity and identify cellular inflammation. Clinical studies using this technique are now emerging. We aimed to report a range of normal R2* values at 1.5 and 3 T in the myocardium and other tissues following ferumoxytol administration, outline the methodology used and suggest solutions to commonly encountered analysis problems. METHODS: Twenty volunteers were recruited: 10 imaged each at 1.5 T and 3 T. T2* and late gadolinium enhanced (LGE) MRI was conducted at baseline with further T2* imaging conducted approximately 24 h after USPIO infusion (ferumoxytol, 4 mg/kg). Regions of interest were selected in the myocardium and compared to other tissues. RESULTS: Following administration, USPIO was detected by changes in R2* from baseline (1/T2*) at 24 h in myocardium, skeletal muscle, kidney, liver, spleen and blood at 1.5 T, and myocardium, kidney, liver, spleen, blood and bone at 3 T (p 

Original publication

DOI

10.1186/s12968-016-0261-2

Type

Journal article

Journal

J cardiovasc magn reson

Publication Date

27/07/2016

Volume

18

Keywords

Cardiac, Inflammation, MRI, USPIO, Artifacts, Contrast Media, Dextrans, Feasibility Studies, Female, Ferrosoferric Oxide, Healthy Volunteers, Heart, Humans, Image Interpretation, Computer-Assisted, Infusions, Intravenous, Magnetic Resonance Imaging, Cine, Magnetite Nanoparticles, Male, Middle Aged, Organometallic Compounds, Predictive Value of Tests, Reproducibility of Results, Tissue Distribution