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OBJECTIVE: To examine the effects of acute insulin-induced hypoglycemia on inflammation, endothelial dysfunction, and platelet activation in adults with and without type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied 16 nondiabetic adults and 16 subjects with type 1 diabetes during euglycemia (blood glucose 4.5 mmol/l) and hypoglycemia (blood glucose 2.5 mmol/l). Markers of inflammation, thrombosis, and endothelial dysfunction (soluble P-selectin, interleukin-6, von Willebrand factor [vWF], tissue plasminogen activator [tPA], high-sensitivity C-reactive protein [hsCRP], and soluble CD40 ligand [sCD40L]) were measured; platelet-monocyte aggregation and CD40 expression on monocytes were determined using flow cytometry. RESULTS: In nondiabetic participants, platelet activation occurred after hypoglycemia, with increments in platelet-monocyte aggregation and P-selectin (P

Original publication




Journal article


Diabetes care

Publication Date





1591 - 1597


Adult, Biomarkers, Blood Glucose, Blood Platelets, C-Reactive Protein, CD40 Antigens, CD40 Ligand, Diabetes Mellitus, Type 1, Diabetic Angiopathies, Endothelium, Vascular, Female, Flow Cytometry, Humans, Hypoglycemia, Hypoglycemic Agents, Inflammation, Insulin, Interleukin-6, Male, Monocytes, P-Selectin, Platelet Activation, Tissue Plasminogen Activator, Vasculitis, von Willebrand Factor