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BACKGROUND: Information from cardiac computed tomography angiography can be summarized using visual semi-quantitative scores. However, the optimal method and their prognostic utility is unknown. METHODS: Five semi-quantitative scores were calculated in the SCOT-HEART trial, including segment involvement score (SIS), segment stenosis score (SSS), CT Leaman (CT-LeSc), multivessel aggregate stenosis score (MVAS), and CAD-RADS 2.0 including plaque modifier (P). Prediction of fatal or non-fatal myocardial infarction and major adverse cardiovascular events (MACE) was compared to the 10-year cardiovascular risk score. RESULTS: Imaging was performed in 1,769 individuals (age 58 ​± ​10 years, 56% male) with 41 (2.3%) experiencing myocardial infarction and 74 (4%) MACE over 4.9 ​± ​1.1 years. P based on calcium score and SIS had good agreement (weighted Cohen's kappa 0.79, 95% confidence interval [CI] 0.79, 0.79). SIS, SSS, CT-LeSec, and MVAS performed similarly for the prediction of myocardial infarction (area under the curve [AUC] 0.74, 0.75, 0.75, 0.74, all p ​> ​0.1) and MACE (AUC 0.73, 0.74, 0.74, 0.73, all p ​> ​0.1), and were superior to the cardiovascular risk score (AUC 0.62 and 0.65, both p ​

Original publication




Journal article


J cardiovasc comput tomogr

Publication Date





393 - 400


Coronary computed tomography angiography (CCTA), Plaque, Semi-quantitative risk scores, Humans, Male, Middle Aged, Aged, Female, Coronary Artery Disease, Prognosis, Computed Tomography Angiography, Coronary Angiography, Constriction, Pathologic, Risk Factors, Predictive Value of Tests, Myocardial Infarction, Tomography, X-Ray Computed