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Membrane-type 1 matrix metalloproteinase (MT1-MMP, also called MMP14) is one of the significant cell invasion drivers. MT1-MMP has been shown to play a crucial role in cancer invasion, cartilage degradation in rheumatoid arthritis, angiogenesis, and collagen homeostasis in different stromal tissues. Thus, investigating MT1-MMP activities in different cell types is of interest to investigators in different research fields. Several methods are available to assess the unique biological activity of MT1-MMP in the cells. This chapter describes various cell-based assays to evaluate unique MT1-MMP activity.

Original publication




Journal article


Methods mol biol

Publication Date





151 - 166


Collagen, Invasion, MT1-MMP, proMMP2 activation, Humans, Matrix Metalloproteinase 14, Collagen, Arthritis, Rheumatoid, Neoplasms, Cartilage